RNAi - Mediated Targeting of Heterochromatin by
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منابع مشابه
RNAi-mediated targeting of heterochromatin by the RITS complex.
RNA interference (RNAi) is a widespread silencing mechanism that acts at both the posttranscriptional and transcriptional levels. Here, we describe the purification of an RNAi effector complex termed RITS (RNA-induced initiation of transcriptional gene silencing) that is required for heterochromatin assembly in fission yeast. The RITS complex contains Ago1 (the fission yeast Argonaute homolog),...
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In Schizosaccharomyces pombe, a fission yeast, large domains of heterochromatin are found at telomeres, silent mating-type loci, and centromeric repeat regions of DNA (Bühler and Moazed, 2007). Much of the work done with S. pombe has shown that the assembly of heterochromatin around centromeric repeats depends on the coordination of two pathways: RNAi and histone modification. Current models su...
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تاریخ انتشار 2008